The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction


Journal article


A. Ceceli, S. King, K. Drury, N. McClain, John H. Gray, P. S. Dassanayake, J. Newcorn, Daniela Schiller, N. Alia-Klein, Rita Z. Goldstein
Proceedings of the National Academy of Sciences of the United States of America, 2025

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APA   Click to copy
Ceceli, A., King, S., Drury, K., McClain, N., Gray, J. H., Dassanayake, P. S., … Goldstein, R. Z. (2025). The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction. Proceedings of the National Academy of Sciences of the United States of America.


Chicago/Turabian   Click to copy
Ceceli, A., S. King, K. Drury, N. McClain, John H. Gray, P. S. Dassanayake, J. Newcorn, Daniela Schiller, N. Alia-Klein, and Rita Z. Goldstein. “The Synergy of Methylphenidate- and Reconsolidation-Based Extinction Normalizes Ventromedial Prefrontal Function in Drug Addiction.” Proceedings of the National Academy of Sciences of the United States of America (2025).


MLA   Click to copy
Ceceli, A., et al. “The Synergy of Methylphenidate- and Reconsolidation-Based Extinction Normalizes Ventromedial Prefrontal Function in Drug Addiction.” Proceedings of the National Academy of Sciences of the United States of America, 2025.


BibTeX   Click to copy

@article{a2025a,
  title = {The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction},
  year = {2025},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  author = {Ceceli, A. and King, S. and Drury, K. and McClain, N. and Gray, John H. and Dassanayake, P. S. and Newcorn, J. and Schiller, Daniela and Alia-Klein, N. and Goldstein, Rita Z.}
}

Abstract

Significance In people with drug addiction, we report that the pharmacological enhancement of memory modulation normalized impairments in prefrontal cortex function in response to drug-associated cues, with effects associated with lab-based drug seeking the following day. These results could contribute to the development of precise therapeutic tools to dampen excessive drug-biased salience for people with addiction, as well as other relevant disorders characterized by a maladaptive response to salient memories (e.g., posttraumatic stress disorder).