Journal article
Pierre-Olivier Gaudreault, S. King, Yuefeng Huang, A. Ceceli, G. Kronberg, N. Alia-Klein, Rita Z. Goldstein
JAMA Network Open, 2024
JAMA Network Open, 2024
Semantic Scholar
DOI
PubMedCentral
PubMed
Cite
Cite
APA
Click to copy
Gaudreault, P.-O., King, S., Huang, Y., Ceceli, A., Kronberg, G., Alia-Klein, N., & Goldstein, R. Z. (2024). Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder. JAMA Network Open.
Chicago/Turabian
Click to copy
Gaudreault, Pierre-Olivier, S. King, Yuefeng Huang, A. Ceceli, G. Kronberg, N. Alia-Klein, and Rita Z. Goldstein. “Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder.” JAMA Network Open (2024).
MLA
Click to copy
Gaudreault, Pierre-Olivier, et al. “Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder.” JAMA Network Open, 2024.
BibTeX Click to copy
@article{pierre-olivier2024a,
title = {Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder},
year = {2024},
journal = {JAMA Network Open},
author = {Gaudreault, Pierre-Olivier and King, S. and Huang, Yuefeng and Ceceli, A. and Kronberg, G. and Alia-Klein, N. and Goldstein, Rita Z.}
}
Abstract
Key Points Question Does white matter microstructure change during medication-assisted treatment in individuals with heroin use disorder (HUD)? Findings In this cohort study of 34 inpatient individuals with HUD and 25 healthy controls, changes in white matter microstructure were associated with treatment in the individuals with HUD cohort, characterized by increased anisotropy and decreased diffusivity in fronto-striatal white matter pathways, which correlated with decreases in baseline drug craving. Meaning These results suggest that frontal white matter changes and associated drug craving decreases are associated with brain-behavior recovery with inpatient treatment in individuals with HUD, potentially contributing to reduced drug use and sustained abstinence.